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Season premiere

Best Medicine Season 2 Episode 1 “Be Careful What You Fish For”

Released on FOX.

Released

Sunday, September 20, 2026

50 days ago

About this episode

While Martin continues to struggle with his blood phobia, a mermaid washes ashore in Port Wenn to the amazement of everyone in town. Meanwhile, Judith, a well-meaning townsperson (guest star Andrea Martin), creates havoc while on prescribed oxygen, Louisa continues to see Martin's girlfriend Eden for medical guidance and Greg and George's success from the seas urchin boom take its toll on the both of them.

Best Medicine Season 2 Episode 1 still
Season
2 (7 episodes)
Runtime
44 min
Network
FOX
Directed by
Nancy Hower
Written by
Liz Tuccillo

Guest stars

  • Carter Shimp

    Carter Shimp

    Al Large

  • John DiMaggio

    John DiMaggio

    Bert Large

  • Clea Lewis

    Clea Lewis

    Sally Mylow

  • Didi Conn

    Didi Conn

    Geneva

  • Ben Lewis Doherty

    Ben Lewis Doherty

    Peter Cronk

  • Wendy Makkena

    Wendy Makkena

    Susan Carlisle

  • Eliza Coupe

    Eliza Coupe

    Dr. Eden Montgomery

  • Alexandra Sica

    Harley

  • Leah Janae Thomas

    Amelia

  • Josh Hoon Lee

    Liam

  • Alison Cimmet

    Alison Cimmet

    Irma

  • Andrea Martin

    Andrea Martin

    Judith

  • Patch Darragh

    Patch Darragh

    Glendon Ross

  • Ellen Nikbakht

    Ellen Nikbakht

    Cecilia

  • Cindy De La Cruz

    Jeannie

  • Camren Carrington

    Faker Tommy

Questions about this episode

When does Best Medicine Season 2 Episode 1 come out?

Best Medicine Season 2 Episode 1 was released Sunday, September 20, 2026 on FOX.

What time does Best Medicine Season 2 Episode 1 come out?

Release times vary by platform and region, so Streambay doesn't list an exact time. The easiest way to know is to follow Best Medicine in the Streambay app, which notifies you the moment the episode is available.

When does the next episode of Best Medicine come out?

Best Medicine S2 E2 was released Tuesday, September 29, 2026.

How long is Best Medicine Season 2 Episode 1?

Best Medicine Season 2 Episode 1 runs about 44 minutes.

Last updated

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