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When does Grey's Anatomy Season 22 come out?

Grey's Anatomy Season 22 premiered Thursday, October 9, 2025 on ABC and ended Thursday, May 7, 2026. The season has 18 episodes.

The twenty-second season will focus on intense, large-scale disasters, including a major bridge collapse bringing in dozens of critically injured patients at Grey Sloan Memorial, alongside high-stakes personnel changes. Dr. Meredith Grey and Dr. Nick Marsh decide to marry after Nick is severely injured in the bridge collapse, with Meredith realizing she doesn't want to let fear dictate her life. The season features the departure of long-time series regulars Dr. Owen Hunt and Dr. Teddy Altman, who leave for a new life in France after surviving a near-fatal plunge in his car during the bridge collapse, marking an end to their long-running storyline.

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Grey's Anatomy Season 22 release schedule

Grey's Anatomy Season 22 episode release dates
Episode Release date

1. Only the Strong Survive

After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

Thursday · 1 year ago

2. We Built This City

The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Meanwhile, Meredith spends time with Amelia.

Thursday · 1 year ago

3. Between Two Lungs

A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.

Thursday · 1 year ago

4. Goodbye Horses

The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.

Thursday · 1 year ago

5. Sometimes I Feel Like a Motherless Child

Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.

Thursday · 1 year ago

6. When I Crash Mid-season finale

Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey's patience.

Thursday · 12 months ago

7. Skyfall

Winston and Ben fight to save Jo's life, while Teddy supports Link. Owen and Jules battle to save a young man, and Lucas forms an unexpected bond with a patient.

Thursday · 10 months ago

8. Heavy on Me

Bailey and Owen join forces to save a tumor patient, while Richard faces an internal battle. Meanwhile, Jules struggles with her feelings for Winston.

Thursday · 9 months ago

9. Fortunate Son

Richard continues to navigate his health. Meanwhile, Meredith and Nick are visited by Nick's estranged sister from Boston.

Thursday · 9 months ago

10. Strip That Down Mid-season finale

Addison Montgomery returns to Grey Sloan, seeking assistance with a patient with a neurological condition. Bailey joins Owen and Blue on a paramedic ride-along.

Thursday · 9 months ago

11. (If You Want It) Do It Yourself

Teddy and Winston clash over a case, while Owen and Jules treat a urologist. Lucas struggles with prioritizing patients.

Thursday · 8 months ago

12. Get Lucky

Tensions rise as Teddy and Winston take on a complex procedure, while Kavita and Ben try and impress the new plastics attending. Jo and Link leave the babies with a nanny for the first time.

Thursday · 8 months ago

13. Love the Way You Lie

Richard tackles a shocking case on his first day back, while Kavita and Jules prepare for a high-stakes presentation. Bailey must have a difficult conversation with a beloved patient, and Jo works to baby-proof the loft.

Thursday · 8 months ago

14. Wrecking Ball

A couple lands in the hospital with life-altering injuries after a wrecking ball destroys their home. Lucas and Simone struggle to support a young, terminally ill patient, and Richard hosts a prostate screening event.

Thursday · 7 months ago

15. Take Me to the River

Bailey and Blue are forced to confront the emotional costs of experimental care. Meanwhile, Owen, Teddy, Simone and Dani help out at a busy rural hospital, and Richard attempts to spread information about early prostate screenings to the community.

Thursday · 7 months ago

16. Feel It Still

Jo returns for her first full day back from leave, and Owen struggles to keep it together when someone close to him is admitted to Grey Sloan. Meanwhile, Bailey navigates hospital leadership.

Thursday · 7 months ago

17. Through the Fire

A Station 19 firefighter lands in the ER for severe burn treatment, and the team treats an elderly patient impaled by an art structure. A Fox Foundation innovation competition reunites Meredith and Bailey.

Thursday · 6 months ago

18. Bridge over Troubled Water Finale

After a catastrophic bridge collapse sends dozens of victims to Grey Sloan, the hospital activates its full disaster response as they race to treat a surge of critically injured patients, including one of their own.

Thursday · 6 months ago

Grey's Anatomy Season 22 guest stars

  • Jesse Williams

    Jesse Williams

    Jackson Avery

  • Kelly McCreary

    Kelly McCreary

    Maggie Pierce

  • Scott Speedman

    Scott Speedman

    Nick Marsh

  • Kate Walsh

    Kate Walsh

    Addison Montgomery

  • Jaicy Elliot

    Jaicy Elliot

    Taryn Helm

  • Branden Silverman

    Branden Silverman

    Paramedic

  • Danielle Savre

    Danielle Savre

    Maya Bishop

  • Debra Mooney

    Debra Mooney

    Evelyn Hunt

  • Payton Silver

    Payton Silver

    Dr. Knox

  • Rasta Thomas

    Rasta Thomas

    Paramedic

  • Norman Nixon, Jr.

    Norman Nixon, Jr.

    Nurse James

  • Avalon Gray

    Leo Hunt

  • Colette Gray

    Leo Hunt

  • River Davidson

    Allison Hunt

  • Frances Nichols

    Frances Nichols

    Nurse Karen

  • Kate Burton

    Kate Burton

    Ellis Grey

Grey's Anatomy Season 22 FAQ

When does Grey's Anatomy Season 22 come out?

Grey's Anatomy Season 22 premiered Thursday, October 9, 2025 on ABC.

How many episodes are in Grey's Anatomy Season 22?

Grey's Anatomy Season 22 has 18 episodes.

Are new episodes of Grey's Anatomy Season 22 released weekly?

New episodes are released weekly.

When is the Grey's Anatomy Season 22 finale?

The Grey's Anatomy Season 22 finale (Episode 18) aired Thursday, May 7, 2026.

How do I get notified when new Grey's Anatomy Season 22 episodes are released?

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